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The Teklanika River is a feeder stream to the Yukon River drainage and a tributary of the Nenana River in the central interior region of Alaska. Flowing from headwaters at the Cantwell Glacier in the Alaska Range and reaching 111 miles (179 km) to the Tanana River, it drains an area widely visited by tourists to Denali National Park and Preserve. The park's only road crosses the river at milepost 31 and a National Park campground is located on its eastern bank at milepost 29.